20-Hydroxyecdysone counteracts insulin to promote programmed cell death by modifying phosphoglycerate kinase 1.

Xin-Le KangYan-Xue LiDu-Juan DongJin-Xing WangXiao-Fan Zhao

Published in: BMC biology (2023)

The posttranslational modification of PGK1 determines its functions in cell proliferation and PCD. Insulin and 20E counteractively regulate PGK1 phosphorylation and acetylation to give it dual functions in cell proliferation and PCD.

Keyphrases

cell proliferation
type diabetes
glycemic control
cell cycle
protein kinase
pi k akt
tyrosine kinase
insulin resistance
adipose tissue
metabolic syndrome
weight loss