In the coming years, artificial intelligence (AI) will pervade almost every aspect of the health care delivery system. AI has the potential to improve patient safety (e.g. diagnostic accuracy) as well as reduce the burden on clinicians (e.g. documentation-related workload); however, these benefits are yet to be realized. AI is only one element of a larger sociotechnical system that needs to be considered for effective AI application. In this paper, we describe the current challenges of integrating AI into clinical care and propose a sociotechnical systems (STS) approach for AI design and implementation. We demonstrate the importance of an STS approach through a case study on the design and implementation of a clinical decision support (CDS). In order for AI to reach its potential, the entire work system as well as clinical workflow must be systematically considered throughout the design of AI technology.