Hepatic inflammation elicits production of proinflammatory netrin-1 through exclusive activation of translation.

Romain Barnault Claire Verzeroli Carole Fournier Maud Michelet Anna-Rita Redavid Ievgeniia Chicherova Marie-Laure Plissonnier Annie Adrait Olga Khomich Fleur Chapus Mathieu RichaudMaëva HervieuVeronika Reiterer Federica Grazia Centonze Julie Lucifora Birke BartoschMichel RivoireHesso Farhan Yohann Cout Valbona Mirakaj Thomas Decaens Patrick Mehlen Benjamin Gibert Fabien Zoulim Romain Parent

Published in: Hepatology (Baltimore, Md.) (2022)

These results identify netrin-1 as an inflammation-inducible factor in the liver through an atypical mechanism as well as its contribution to hepatic inflammation.

Keyphrases

oxidative stress