Clinical and Molecular Spectrum of Nonsyndromic Early-Onset Osteoarthritis.

Valentin RuaultKevin YauyAurélie FabreMélanie FradinJulien Van-GilsChloé AngeliniGeneviève BaujatPatricia BlanchetSilvestre CuinatBertrand IsidorChristian JorgensenDidier LacombeSébastien MouttonSylvie OdentElodie SanchezSabine SigaudyIsabelle TouitouMarjolaine WillemsFlorence ApparaillyDavid GenevièveMouna Barat-Houari

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

We confirmed that COL2A1 is the main monogenic cause of nonsyndromic early-onset OA. However, on the basis of genetic heterogeneity of early-onset OA, we recommend next-generation sequencing for all individuals who undergo joint replacement prior to the age of 45 years. Lifestyle recommendations for prevention should be implemented.

Keyphrases

early onset
late onset
knee osteoarthritis
copy number
rheumatoid arthritis
metabolic syndrome
physical activity
single cell
genome wide
weight loss
gene expression
type diabetes
dna methylation
circulating tumor