Vorinostat in the acute neuroinflammatory form of X-linked adrenoleukodystrophy.
Bettina ZierfussIsabelle WeinhoferJörn-Sven KühlWolfgang KöhlerAnnette BleyKatharina ZaunerJohannes BinderKsenija MartinovićChristian SeiserChristoph HertzbergStephan KempGerda EggerGerda LeitnerJan BauerChristoph WiesingerMarkus KunzeSonja Forss-PetterJohannes BergerPublished in: Annals of clinical and translational neurology (2020)
The beneficial effects of HDAC inhibitors on macrophages in X-ALD and the improvement of the blood-CSF/blood-brain barrier are encouraging for future investigations. In contrast with Vorinostat, less toxic macrophage-specific HDAC inhibitors might improve also the clinical state of X-ALD patients with advanced inflammatory demyelination.