Antibody Responses to Citrullinated and Noncitrullinated Antigens in the Sputum of Subjects With Rheumatoid Arthritis and Subjects at Risk for Development of Rheumatoid Arthritis.
M Kristen DemoruelleEmily BowersLauren J LaheyJeremy SokoloveMonica M PurmalekNickie L SetoMichael H WeismanJill M NorrisMariana J KaplanV Michael HolersWilliam H RobinsonKevin D DeanePublished in: Arthritis & rheumatology (Hoboken, N.J.) (2018)
These findings suggest that sputum antibody reactivity to particular citrullinated and noncitrullinated proteins/peptides is specific for RA and for subjects at risk of RA, and the association of these proteins/peptides with NETs may be a key feature of early RA-related autoimmunity in the lung. These results further support the hypothesis that the lung plays a role in early RA-related autoimmunity.