Selective galactose culture condition reveals distinct metabolic signatures in pyruvate dehydrogenase and complex I deficient human skin fibroblasts.

Damian HertigAndrea FelserGaëlle DiserensSandra KurthPeter VermathenJean-Marc Nuoffer

Published in: Metabolomics : Official journal of the Metabolomic Society (2019)

Our results show the relevance of selective culture methods in discriminating normal from metabolic deficient cells. The study indicates that untargeted fingerprinting NMR profiles provide physiological insight on metabolic adaptations and can be used to distinguish cellular metabolic adaptations in PDH and complex I deficient fibroblasts.

Keyphrases

induced apoptosis
magnetic resonance
cell cycle arrest
high resolution
high intensity
extracellular matrix
cell death
dna methylation
genome wide
signaling pathway
gas chromatography mass spectrometry