Enhanced Fluorescence Imaging and Photodynamic Cancer Therapy Using Hollow Mesoporous Nanocontainers.
Suk Ho HongHyunjin KimYongdoo ChoiPublished in: Chemistry, an Asian journal (2017)
Here we show that "off-on" type of photodynamic therapy agents could be developed using hollow mesoporous silica nanoparticles (HMSNPs), which can be used not only for enhancing delivery of photosensitizers to cancer cells but also for enabling switchable optical properties of the photosensitizers. Fluorescence and singlet oxygen generation of the photosensitizer-loaded HMSNP are turned off in its native state. In vitro cell studies showed that this HMSNP-based "off-on" agent may have potential utility in selective fluorescence detection and photodynamic therapy of cancers.
Keyphrases
- photodynamic therapy
- fluorescence imaging
- cancer therapy
- drug delivery
- energy transfer
- metal organic framework
- single molecule
- molecularly imprinted
- single cell
- cell therapy
- highly efficient
- loop mediated isothermal amplification
- real time pcr
- stem cells
- case control
- human health
- label free
- mesenchymal stem cells
- risk assessment
- walled carbon nanotubes