Systemic Rho-kinase inhibition using fasudil in mice with oxygen-induced retinopathy.
Claudia BrockmannCaitlin CorkhillElzbieta JaroslawskaSabrina DegeTobias BrockmannNorbert KociokAntonia M JoussenPublished in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2019)
In conclusion, our findings support that daily systemic application of fasudil does not decrease retinal neovascularization in rodents with oxygen-induced retinopathy. The results of our study together with the controversial results on the effects of different ROCK inhibitors from the literature makes it apparent that effects of ROCK inhibition are more complex, and further studies are necessary to analyze its potential therapeutic effects.
Keyphrases
- high glucose
- diabetic rats
- drug induced
- diabetic retinopathy
- systematic review
- protein kinase
- optical coherence tomography
- physical activity
- metabolic syndrome
- skeletal muscle
- computed tomography
- tyrosine kinase
- vascular endothelial growth factor
- insulin resistance
- high fat diet induced
- smooth muscle
- stress induced