Association of early dexamethasone therapy with mortality in critically Ill COVID-19 patients: a French multicenter study.

Matthieu RaymondAurélie Le ThuautPierre AsfarCédric DarreauFlorian ReizineGwenhaël ColinCharly DanoJulien LorberBaptiste HourmantAgathe DelboveAurélien FrérouJean MorinPierre Yves EgreteauPhilippe SeguinJean ReignierJean-Baptiste LascarrouEmmanuel Canet

Published in: Annals of intensive care (2022)

Early dexamethasone in critically ill COVID-19 patients was not associated with lower day-28 mortality. However, early dexamethasone was associated with lower intubation needs and more ventilator-free days by day 28. In patients treated with invasive mechanical ventilation, early dexamethasone was associated with a higher risk of VAP.

Keyphrases

mechanical ventilation
low dose
high dose
sars cov
acute respiratory distress syndrome
intensive care unit
cardiovascular events
cardiac arrest
stem cells
bone marrow
respiratory failure