Effects of caffeine on intracranial pressure and pain perception in freely moving rats.
Ida Marchen Egerod IsraelsenConnar Stanley James WestgateChristina Kamp-JensenRigmor Hoejland JensenSajedeh EftekhariPublished in: Headache (2023)
This study demonstrates that caffeine has a lowering effect on ICP as an acute treatment. Interestingly, caffeine acutely caused an increased response in cephalic thresholds supporting hypoalgesic effects. Future studies investigating the beneficial effects of caffeine for elevated ICP are warranted.