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Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer's disease in the EMIF-AD study.

Rebecca G SmithEhsan PishvaMorteza KouhsarJennifer ImmValerija DobricicPeter JohannsenMichael WittigAndre FrankeRik VandenbergheJolien SchaeverbekeYvonne Freund-LeviLutz FrölichPhilip ScheltensCharlotte E TeunissenGiovanni FrisoniOlivier BlinJill C RichardsonRégis BordetSebastiaan EngelborghsEllen de RoeckPablo Martinez-LageMiren AltunaMikel TaintaAlberto LleóIsabel SalaJulius PoppGwendoline PeyratoutLaura WinchesterAlejo Nevado-HolgadoFrans VerheyMagda TsolakiUlf AndreassonKaj BlennowHenrik ZetterbergJohannes StrefferStephanie J B VosSimon LovestonePieter Jelle VisserLars BertramKatie Lunnon
Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Blood DNA methylation was assessed in the EMIF-AD MBD study. Epigenome-wide association studies (EWASs) were performed for 15 Alzheimer's disease (AD)-relevant cerebrospinal fluid (CSF) biomarker measures. Five Bonferroni-significant loci were associated with YKL-40 levels and seven with neurofilament light chain (NfL). DNA methylation in YKL-40 co-localized with previously reported genetic variation. DNA methylation potentially mediates the effect of single-nucleotide polymorphisms (SNPs) in YKL-40 on CSF protein levels.
Keyphrases
  • dna methylation
  • genome wide
  • cerebrospinal fluid
  • gene expression
  • copy number
  • single molecule
  • small molecule
  • binding protein
  • nucleic acid
  • circulating tumor cells