Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells.

Patrick J BrennanRebecca E SaundersMary SpanouMarta SerafiniLiang SunGuillaume P HegerAgnieszka KonopackaRyan D BeveridgeLaurie GordonShenaz B BunallyAurore SaudemontAndrew B BenowitzCarlos Martinez-FleitesMarkus A QueisserHeeseon An Charlotte M Deane Michael M Hann Lewis L Brayshaw Stuart J Conway

Published in: bioRxiv : the preprint server for biology (2024)

Engineered zinc-finger-based degrons enable targeted protein degradation induced by selective molecular glues.

Keyphrases

induced apoptosis
protein protein
amino acid
cell cycle arrest
binding protein
signaling pathway
cell proliferation