Tumor Cell-Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer.

Samara P Singh Austin R Dosch Siddharth Mehra Iago De Castro Silva Anna Bianchi Vanessa T Garrido Zhiqun Zhou Andrew Adams Haleh Amirian Edmond W Box Xiaodian Sun Yuguang J Ban Jashodeep Datta Nagaraj S Nagathihalli Nipun B Merchant

Published in: Cancer research (2024)

Inhibition of p38 MAPK suppresses tumor cell-derived IL1α and attenuates the inflammatory stroma and immunosuppressive tumor microenvironment to overcome chemotherapeutic resistance in pancreatic cancer.

Keyphrases

oxidative stress
bone marrow
single cell
signaling pathway
cell therapy
mesenchymal stem cells