Estrogen prevents age-dependent beige adipogenesis failure through NAMPT-controlled ER stress pathway.

Jooman ParkRuoci HuShaolei XiongYanyu QianAsma Sana El-SabbaghMeram IbrahimQing SongGege YanZhenyuan SongAbeer M MahmoudYanlin HeBrian T LaydenJiwang ChenSang-Ging OngPingwen XuYuwei Jiang

Published in: bioRxiv : the preprint server for biology (2023)

Estrogen restores beige adipocyte failure along with improved energy metabolism in old mice.Estrogen enhances the thermogenic gene program by mitigating age-induced ER stress.Estrogen enhances the beige adipogenesis derived from SMA+ APCs.Inhibiting the NAMPT signaling pathway abolishes estrogen-promoted beige adipogenesis.

Keyphrases

estrogen receptor
signaling pathway
high fat diet induced
insulin resistance
pi k akt
type diabetes
high glucose
metabolic syndrome
quality improvement
epithelial mesenchymal transition
genome wide
copy number
drug induced
transcription factor
endothelial cells
stress induced