P2Y12 inhibitor use predicts hematoma expansion in patients with intracerebral hemorrhage.

Ethan J HouskampYuzhe LiuJuliana Silva Pinheiro do NascimentoBabak S JahromiPaul F LindholmHau C KwaanAndrew M Naidech

Published in: Annals of clinical and translational neurology (2024)

Patients taking a P2Y12 inhibitor had more HE and less P2Y12 activity. The effect was most pronounced in patients on DAPT, suggesting a synergistic effect of P2Y12 inhibitors and aspirin with respect to HE. Acute reversal of P2Y12 inhibitors in acute ICH requires further study.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
liver failure
type diabetes
respiratory failure
antiplatelet therapy
percutaneous coronary intervention
aortic dissection
extracorporeal membrane oxygenation