Nickel-Catalyzed Kumada Coupling of Boc-Activated Aromatic Amines via Nondirected Selective Aryl C-N Bond Cleavage.
Zheng-Bing ZhangChong-Lei JiCe YangJie ChenXin HongJi-Bao XiaPublished in: Organic letters (2019)
A nickel-catalyzed Kumada coupling of aniline derivatives was developed by selective cleavage of aryl C-N bonds under mild reaction conditions. Without preinstallation of an ortho directing group on anilines, the cross-coupling reactions of Boc-protected aromatic amines with aryl Grignard reagents afforded unsymmetric biaryls. Mechanistic studies by DFT calculations revealed that the nickel-mediated C-N bond cleavage is the rate-limiting step.
Keyphrases
- room temperature
- dna binding
- reduced graphene oxide
- density functional theory
- oxide nanoparticles
- electron transfer
- carbon nanotubes
- metal organic framework
- amino acid
- ionic liquid
- transition metal
- molecular dynamics
- molecular dynamics simulations
- transcription factor
- gold nanoparticles
- case control
- structure activity relationship