Analysis of anti-apoptotic PVT1 oncogene and apoptosis-related proteins (p53, Bcl2, PD-1, and PD-L1) expression in thyroid carcinoma.

Afaf T Ibrahiem Amin K Makhdoom Khalid S Alanazi Abdulaziz M Alanazi Abdulaziz M MukhlefSaad H ElshafeyEman Ali Toraih Manal S Fawzy

Published in: Journal of clinical laboratory analysis (2022)

Our results confirm the upregulation of PVT1 in TC. The apoptosis-related proteins (p53, Bcl2, and PD-1/PD-L1) showed different prognostic utility in TC patients; in particular, low p53 and high PD-L1 expressions associated with low survival times. Further large-scale and mechanistic studies are warranted.

Keyphrases

cell death
end stage renal disease
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
chronic kidney disease
newly diagnosed
prognostic factors
cell proliferation
drug induced