Drug-Induced Progressive Multifocal Leukoencephalopathy (PML): A Systematic Review and Meta-Analysis.
Lorenzo Vittorio RindiDrieda ZaceNeva BraccialargheBarbara MassaVirginia BarchiRoberta IannazzoIlenia FatoFrancesco De MariaDimitra KontogiannisVincenzo MalagninoLoredana SarmatiMarco IannettaPublished in: Drug safety (2024)
A higher risk of drug-related PML in patients whose immune system is not additionally depressed by means of neoplasms, HIV or concomitant medications is found in the neurological field. This risk is higher in MS treatment, and specifically during long-term natalizumab therapy. While this drug is still routinely prescribed in this field, considering the efficacy in reducing MS relapses, in other areas it could play a smaller role, and be gradually replaced by other safer and more recently approved agents.
Keyphrases
- drug induced
- multiple sclerosis
- liver injury
- end stage renal disease
- mass spectrometry
- newly diagnosed
- ms ms
- ejection fraction
- adverse drug
- chronic kidney disease
- antiretroviral therapy
- hiv infected
- human immunodeficiency virus
- hepatitis c virus
- peritoneal dialysis
- hiv aids
- hiv positive
- stem cells
- hiv testing
- patient reported outcomes
- combination therapy
- south africa
- replacement therapy
- men who have sex with men
- bone marrow
- drug administration