Metabolomics analysis in adults with high bone mass identifies a relationship between bone resorption and circulating citrate which replicates in the general population.
April E HartleyLavinia PaternosterDavid M EvansWilliam D FraserJonathan C Y TangDebbie A LawlorJon H TobiasCelia L GregsonPublished in: Clinical endocrinology (2019)
Bone resorption is positively related to circulating citrate and inversely related to triglycerides. Further studies are justified to determine whether plasma citrate or triglyceride concentrations are altered by factors known to modulate bone resorption, such as bisphosphonates.