Hypoperfusion Precedes Tau Deposition in the Entorhinal Cortex: A Retrospective Evaluation of ADNI-2 Data.
Anish N KapadiaKrish BillimoriaPrarthna DesaiJames T GristChinthaka C HeynPejman Jabehdar MaralaniSean SymonsFulvio ZaccagnaPublished in: Journal of clinical neurology (Seoul, Korea) (2023)
The results of this study suggest that a reduction in CBF at the entorhinal cortex precedes tau deposition. Further work is needed to understand the mechanism underlying tau deposition in aging and disease.