Induced pluripotent stem cells can improve thrombolytic effect of low-dose rt-PA after acute carotid thrombosis in rat.

Hsi-Lung HsiehChing-Chung LiangCheng-You LuJen-Tsung YangChiu-Yen ChungYu-Shien KoTsong-Hai Lee

Published in: Stem cell research & therapy (2021)

The adjuvant use of iPSCs may help improving the thrombolytic effect of low-dose rt-PA by suppressing inflammatory factors and inducing angiogenic trophic factors. Stem cells could be a potential regimen in acute thrombolytic therapy to improve recanalization and reduce complications.

Keyphrases

low dose
pulmonary embolism
induced pluripotent stem cells
stem cells
acute ischemic stroke
high dose
oxidative stress
liver failure
early stage
risk factors
respiratory failure
cell therapy
hepatitis b virus
mesenchymal stem cells
mechanical ventilation