Fibrin clot quality in acutely ill cirrhosis patients: relation with outcome and improvement with coagulation factor concentrates.
Annabel BlasiVishal C PatelEva N H E SpankeJelle AdelmeijerMarilena StamouliAne ZamalloaEleanor CorcoranAndrea CalvoJavier FernandezWilliam BernalJ P LuyendykPublished in: Liver international : official journal of the International Association for the Study of the Liver (2021)
We have demonstrated elevated thrombin generation but decreased plasma levels of prothrombin, fibrinogen and FXIII in acutely ill patients with cirrhosis. In addition, we showed that fibrinogen concentrate and PCCs, but not factor XIII concentrate, improve clot properties in patient plasma. Whether there is true clinical benefit from coagulation factor concentrates in prevention or treatment of bleeding requires further study.