Quantitative MR neurography biomarkers in 5q-linked spinal muscular atrophy.
Jennifer C HayesTim HilgenfeldAndreas ZieglerAfshin SaffariGeorges SamJohn M HayesAdriana PietschMarie JostSabine HeilandMartin BendszusWolfgang WickMarkus WeilerPublished in: Neurology (2019)
MRN detects and quantifies peripheral nerve involvement in SMA types II, IIIa, and IIIb with high sensitivity in vivo. Quantitative MRN parameters (T2 relaxation time, proton spin density, CSA) might serve as novel imaging biomarkers in SMA to indicate early microstructural nerve tissue changes in response to treatment.