Comparison of plasma and oral fluid concentrations of mycophenolic acid and its glucuronide metabolite by LC-MS in kidney transplant patients.
Pamela Cristina Lukasewicz FerreiraFlavia Valladao ThiesenThaina Tavares de AraujoDomingos Otávio D'ÁvilaGiovani GadonskiCarmem Silvana A de OliveiraAline Rigon ZimmerPedro Eduardo FröehlichPublished in: European journal of clinical pharmacology (2019)
After comparing plasma and oral fluid concentrations as well as performing a non-compartmental pharmacokinetic analysis of the average curves, it is possible to suggest that oral fluid concentration may be used as an alternative for MPA and MPAG monitoring in kidney transplant patients.