Thymoquinone ameliorates delayed cerebral injury and cerebral vasospasm secondary to experimental subarachnoid haemorrhage.

Enes AkkayaŞevket EvranFatih ÇalışSerdar ÇevikSalim KatarErsin KarataşAbdurrahim KoçyiğitMustafa Yasin SağlamMustafa Aziz HatiboğluHakan HanımoğluMehmet Yaşar Kaynar

Published in: Neurologia i neurochirurgia polska (2020)

Our results show that post-SAH TQ inhibits/improves DCI and cVS with positive effects on oxidative stress, apoptosis, ET-1, lumen area, and vessel wall thickness, probably due to its anti-ischaemic, antispasmodic, antioxidant, anti-inflammatory, anti-apoptotic and neuroprotective effects.

Keyphrases

oxidative stress
anti inflammatory
subarachnoid hemorrhage
cell death
brain injury
cerebral ischemia
dna damage
ischemia reperfusion injury
optical coherence tomography
induced apoptosis
mouse model
cerebral blood flow
ultrasound guided
signaling pathway
cell proliferation