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GSK3B Overexpression Alleviates Posttraumatic Osteoarthritis in Mice by Promoting DNMT1-Mediated Hypermethylation of NR4A3 Promoter.

Zhou LvDeping SunXin LiGang Wu
Published in: Disease markers (2022)
GSK3B recruits DNMT1 to the NR4A3 promoter region and inhibits the activation of the NR4A3-mediated JAK2/STAT3 signaling pathway, thereby alleviating PTOA.
Keyphrases
  • dna methylation
  • signaling pathway
  • pi k akt
  • transcription factor
  • gene expression
  • cell proliferation
  • epithelial mesenchymal transition
  • rheumatoid arthritis
  • oxidative stress
  • adipose tissue