Impact of age, sex and CYP genotype on quetiapine- and N-desalkylquetiapine serum concentrations - A study based on real-world data from 8118 patients.

Vigdis SolhaugMarit TveitoRagnhild Birkeland WaadeGudrun HøisethEspen Molden Robert Løvsletten Smith

Published in: British journal of clinical pharmacology (2023)

This study shows an increase of the QUE and NDQ exposures during aging. Old age, female sex and CYP2D6 allele variants encoding reduced activity are factors associated with high NDQ exposure. Therefore, females ≥65y carrying CYP2D6 allele variants encoding reduced activity have the highest risk of dose-dependent side effects of NDQ during QUE treatment.

Keyphrases

end stage renal disease
copy number
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
air pollution
machine learning
big data
data analysis