The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis.
Katherine E StephensonJoanne PorteAoife KellyWilliam A WallaceCatherine E HuntingtonCatherine L Overed-SayerE Suzanne CohenR Gisli JenkinsAlison E JohnPublished in: Respiratory research (2023)
Together these findings suggest the IL-33:ST2 axis does not play a central fibrogenic role in the lungs with therapeutic blockade of this pathway unlikely to surpass the current standard of care for IPF.