FAME-04: A Phase 1 trial to assess the safety, acceptability, pharmacokinetics and pharmacodynamics of film and gel formulations of tenofovir.

Katherine E BungeCharlene S DezzuttiCraig W HendrixMark A MarzinkeHans M L SpiegelBernard J MonclaJill L SchwartzLeslie A MeynNicola Richardson-HarmanLisa C RohanSharon L Hillier

Published in: Journal of the International AIDS Society (2019)

Films were safe and well tolerated. Furthermore, films delivered TFV to mucosal tissues at concentrations similar to gel and were sufficient to block HIV infection of genital tissue ex vivo.

Keyphrases

room temperature
antiretroviral therapy
wound healing
gene expression
hyaluronic acid
ionic liquid
carbon nanotubes
ulcerative colitis
reduced graphene oxide
gold nanoparticles