Integrated analysis of patients with KEAP1/NFE2L2/CUL3 mutations in lung adenocarcinomas.

Xing JinYuansheng ZhengZhencong ChenFei WangGuoshu BiMing LiJiaqi LiangQihai SuiYunyi BianZhengyang HuYulei QiaoSong-Tao Xu

Published in: Cancer medicine (2021)

This research implemented the comprehensive analysis of KEAP1/NFE2L2/CUL3 somatic mutations in the LUAD patients. Compared with the wild type of LUAD patients, the Mut group shows a large difference in clinical features, RNA sequence, DNA methylation, and immune infiltrations, indicating complex mechanism oncogenesis and also reveals potential therapeutic targets.

Keyphrases

end stage renal disease
dna methylation
chronic kidney disease
newly diagnosed
ejection fraction
prognostic factors
gene expression
wild type
risk assessment