Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study.
Victoria RodriguezLuis AlamedaDiego QuattroneGiada TripoliCharlotte Gayer-AndersonEdoardo SpinazzolaGiulia TrottaHannah E JongsmaSimona StiloCaterina La CasciaLaura FerraroDaniele La BarberaAntonio LasalviaSarah TosatoIlaria TarriconeElena BonoraStéphane JamainJean-Paul SeltenEva VelthorstLieuwe de HaanPierre-Michel LlorcaManuel ArrojoJulio BobesMiguel BernardoCelso ArangoJames KirkbridePeter B JonesBart P RuttenAlexander RichardsPak C ShamMichael O'DonovanJim Van OsCraig MorganMarta Di FortiRobin M MurrayEvangelos VassosPublished in: Psychological medicine (2022)
Combining PRS for severe psychiatric disorders in prediction models for psychosis phenotypes can increase discriminative ability and improve our understanding of these phenotypes. Our results point towards the potential usefulness of PRSs in specific populations such as high-risk or early psychosis phases.