Potential drug-drug interaction and its determinants among patients with cancer receiving chemotherapy in oncology centres of Northwest Ethiopia: an institutional-based cross-sectional study.

Samuel Agegnew Wondm Fasil Bayafers TameneKale GubaeSamuel Berihun DagnewAsres Agegnehu WorkuEyayaw Ashete Belachew

Published in: BMJ open (2023)

The main finding of this study is the high prevalence of PDDI, signifying the need for strict patient monitoring for PDDIs among patients with cancer receiving chemotherapy. We suggest the use of at least three drug databases for quality screening. Patients with an age ≥50 years old, polypharmacy and comorbidity were significantly associated with PDDIs. The establishment of oncology clinical pharmacists and computerised reminder mechanisms for PDDIs through drug utilisation review is suggested.

Keyphrases

adverse drug
palliative care
drug induced
emergency department
case report
primary care
radiation therapy
machine learning
risk assessment
rectal cancer
artificial intelligence