A self-triggered radioligand therapy agent for fluorescence imaging of the treatment response in prostate cancer.

Hongchuang XuYanpu WangJingming ZhangXiaojiang DuanTing ZhangXuekang CaiHyunsoo HaYoungjoo ByunYan FanZhi YangYiguang WangZhaofei LiuXing Yang

Published in: European journal of nuclear medicine and molecular imaging (2022)

Probe 2 can potently bind to PSMA, and the fluorescence signal can be sensitively switched on by caspase-3 both in vitro and in vivo. This method may provide an effective tool to investigate and optimize PSMA-RLT.

Keyphrases

fluorescence imaging
pet ct
prostate cancer
pet imaging
photodynamic therapy
radical prostatectomy
cell death
quantum dots
positron emission tomography
induced apoptosis
energy transfer
computed tomography
endoplasmic reticulum stress