Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery.
Kenly WuputraMing-Ho TsaiKohsuke KatoChia-Chen KuJia-Bin PanYa-Han YangShigeo SaitoChun-Chieh WuYing-Chu LinKuang-Hung ChengKung-Kai KuoMichiya NoguchiYukio NakamuraTohru YoshiokaDeng-Chyang WuChang-Shen LinKazunari K YokoyamaPublished in: Inflammation and regeneration (2023)
Jdp2 plays a critical role in AhR promoter activation through the AhR-Jdp2-Nrf2 axis in a spatiotemporal manner. The AhR functions to maintain ROS balance and cell spreading, invasion, and cancer regression in a mouse model of mutant Kras-Trp53 pancreatic cancer. These findings provide new insights into the roles of Jdp2 in the homeostatic regulation of oxidative stress and in the antioxidation response in detoxification, inflammation, and cancer progression.
Keyphrases
- oxidative stress
- papillary thyroid
- mouse model
- dna damage
- squamous cell
- gene expression
- transcription factor
- diabetic rats
- dna methylation
- ischemia reperfusion injury
- single cell
- induced apoptosis
- genome wide
- wild type
- stem cells
- cell migration
- squamous cell carcinoma
- childhood cancer
- reactive oxygen species
- mesenchymal stem cells
- nuclear factor
- immune response
- inflammatory response
- genome wide identification