An LC-MS-based designated comparison method with similar performance to the Lp(a) reference measurement procedure to guide molar Lp(a) standardization.
Nina M DiederiksL Renee RuhaakFred P H T M RomijnMervin M PieterseNico P M SmitChrista M CobbaertPublished in: Clinical proteomics (2024)
The semi-automated, higher throughput, LC-MS-based method for Lp(a) meets the predefined analytical performance specifications and allowable MU and is hence applicable as a higher order Designated Comparison Method, which is ideally suited to guide IVD manufacturers in the transition from Lp(a) mass to molar units.
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