Mitomycin C induces pulmonary vascular endothelial-to-mesenchymal transition and pulmonary veno-occlusive disease via Smad3-dependent pathway in rats.
Chenting ZhangWenju LuXiaoyun LuoShiyun LiuYi LiQiuyu ZhengWenyan LiuXuefen WuYuqin ChenQian JiangZizhou ZhangGuoping GuJiyuan ChenHaixia ChenJing LiaoChunli LiuCheng HongHaiyang TangDejun SunKai YangJian WangPublished in: British journal of pharmacology (2020)
Our data indicated that targeted inhibition of Smad3 leads to a potential, novel strategy for PVOD therapy, likely by inhibiting the EndoMT in pulmonary microvasculature.
Keyphrases
- sickle cell disease
- pulmonary hypertension
- epithelial mesenchymal transition
- transforming growth factor
- stem cells
- extracorporeal membrane oxygenation
- signaling pathway
- bone marrow
- endothelial cells
- electronic health record
- risk assessment
- cancer therapy
- big data
- mesenchymal stem cells
- drug delivery
- endovascular treatment