Biocompatibility and Antibacterial Properties of ZnO-Incorporated Anodic Oxide Coatings on TiZrNb Alloy.
Oleksandr OleshkoYevgeniia HusakViktoriia V KorniienkoRoman PshenychnyiYuliia VaravaAleksei KalinkevichMarcin PisarekKarlis GrundstainsOksana PogorielovaOleg MishchenkoWojciech SimkaRoman ViterMaksym PogorielovPublished in: Nanomaterials (Basel, Switzerland) (2020)
In a present paper, we demonstrate novel approach to form ceramic coatings with incorporated ZnO nanoparticles (NPs) on low modulus TiZrNb alloy with enhanced biocompatibility and antibacterial parameters. Plasma Electrolytic Oxidation (PEO) was used to integrate ZnO nanoparticles (average size 12-27 nm), mixed with Ca(H2PO2)2 aqueous solution into low modulus TiZrNb alloy surface. The TiZrNb alloys with integrated ZnO NPs successfully showed higher surface porosity and contact angle. XPS investigations showed presence of Ca ions and absence of phosphate ions in the PEO modified layer, what explains higher values of contact angle. Cell culture experiment (U2OS type) confirmed that the surface of as formed oxide-ZnO NPs demonstrated hydrophobic properties, what can affect primary cell attachment. Further investigations showed that Ca ions in the PEO coating stimulated proliferative activity of attached cells, resulting in competitive adhesion between cells and bacteria in clinical situation. Thus, high contact angle and integrated ZnO NPs prevent bacterial adhesion and considerably enhance the antibacterial property of TiZrNb alloys. A new anodic oxide coating with ZnO NPs could be successfully used for modification of low modulus alloys to decrease post-implantation complications.
Keyphrases
- quantum dots
- room temperature
- aqueous solution
- visible light
- reduced graphene oxide
- induced apoptosis
- oxide nanoparticles
- high resolution
- light emitting
- cell cycle arrest
- silver nanoparticles
- cystic fibrosis
- ionic liquid
- single cell
- endoplasmic reticulum stress
- gold nanoparticles
- cell therapy
- photodynamic therapy
- protein kinase
- bone marrow
- escherichia coli
- oxidative stress
- signaling pathway
- mesenchymal stem cells
- pseudomonas aeruginosa
- staphylococcus aureus
- hydrogen peroxide
- electron transfer
- water soluble
- walled carbon nanotubes