Icariside II preconditioning evokes robust neuroprotection against ischaemic stroke, by targeting Nrf2 and the OXPHOS/NF-κB/ferroptosis pathway.

Jianmei GaoCongjian MaDianya XiaNana ChenJianyong ZhangFan XuFei LiYuqi HeQi-Hai Gong

Published in: British journal of pharmacology (2022)

ICS II preconditioning provides robust neuroprotection against ischaemic stroke via the astrocytic Nrf2-mediated OXPHOS/NF-κB/ferroptosis axis. Thus, ICS II could be a promising Nrf2 activator to treat ischaemic stroke.

Keyphrases

oxidative stress
cerebral ischemia
ischemia reperfusion injury
nuclear factor
signaling pathway
cell death
brain injury
lps induced
pi k akt
subarachnoid hemorrhage
immune response