KDM5A demethylase: Erasing histone modifications to promote repair of DNA breaks.

Published in: The Journal of cell biology (2017)

Repairing DNA breaks within the complexity of the cell chromatin is challenging. In this issue, Gong et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201611135) identify the histone demethylase KDM5A as a critical editor of the cells' "histone code" that is required to recruit DNA repair complexes to DNA breaks.

Keyphrases

dna repair
circulating tumor
dna damage
dna methylation
cell free
single molecule
single cell
cell therapy
induced apoptosis
gene expression
genome wide
nucleic acid
dna damage response
stem cells
oxidative stress
cell cycle arrest
circulating tumor cells
cell proliferation
endoplasmic reticulum stress