Time-sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis.
Marc Fernandez-GuerreroSofia ZdralAlejandro Castilla-IbeasLucille Lopez-DelisleDenis DubouleMarian A RosPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)
We interpret the transcriptomic data in light of the known development pattern and we conclude that a major transcriptional transition occurs in distal limb buds between E9.5 and E10.5, coincident with the switch from an early phase continuation of the signature of trunk progenitors, related to the initial proximo distal specification, to a late intrinsic phase of development.