Time-sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis.

Marc Fernandez-GuerreroSofia ZdralAlejandro Castilla-IbeasLucille Lopez-DelisleDenis Duboule Marian A Ros

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)

We interpret the transcriptomic data in light of the known development pattern and we conclude that a major transcriptional transition occurs in distal limb buds between E9.5 and E10.5, coincident with the switch from an early phase continuation of the signature of trunk progenitors, related to the initial proximo distal specification, to a late intrinsic phase of development.

Keyphrases

minimally invasive
single cell
gene expression
electronic health record
transcription factor
rna seq
big data
oxidative stress
machine learning
lower limb
artificial intelligence