Confounders and Pharmacological Characterization When Using the QT, JTp, and Tpe Intervals in Beagle Dogs.

Emmanuel BoulayEric TroncyMichael V AccardiMichael K PugsleyAnne-Marie DowneyLois MiraucourtHai HuangAriane MenardWendy TanMichelle Dubuc-MageauAudrey SanfaconMireille GuerrierSimon Authier

Published in: International journal of toxicology (2020)

Results highlight potential confounders on QTc interval, but also on JTpca and Tpeca intervals in nonclinical studies. These potential confounding effects may be relevant to the interpretation of ECG data obtained from nonclinical drug safety studies with Beagle dogs.

Keyphrases

case control
human health
drug induced
big data
heart rate
climate change