Ultrasensitive NO Sensor Based on a Nickel Single-Atom Electrocatalyst for Preliminary Screening of COVID-19.
Wei ZhouYi TanJing MaXiao WangLi YangZhen LiChengcheng LiuHao WuLei SunWei-Qiao DengPublished in: ACS sensors (2022)
A new coronavirus, SARS-CoV-2, has caused the coronavirus disease-2019 (COVID-19) epidemic. A rapid and economical method for preliminary screening of COVID-19 may help to control the COVID-19 pandemic. Here, we report a nickel single-atom electrocatalyst that can be printed on a paper-printing sensor for preliminary screening of COVID-19 suspects by efficient detection of fractional exhaled nitric oxide (FeNO). The FeNO value is confirmed to be related to COVID-19 in our exploratory clinical study, and a machine learning model that can accurately classify healthy subjects and COVID-19 patients is established based on FeNO and other features. The nickel single-atom electrocatalyst consists of a single nickel atom with N 2 O 2 coordination embedded in porous acetylene black (named Ni-N 2 O 2 /AB). A paper-printed sensor was fabricated with the material and showed ultrasensitive response to NO in the range of 0.3-180 ppb. This ultrasensitive sensor could be applied to preliminary screening of COVID-19 in everyday life.
Keyphrases
- sars cov
- coronavirus disease
- respiratory syndrome coronavirus
- metal organic framework
- nitric oxide
- machine learning
- gold nanoparticles
- molecular dynamics
- quantum dots
- reduced graphene oxide
- loop mediated isothermal amplification
- carbon nanotubes
- clinical trial
- mass spectrometry
- electron transfer
- deep learning
- high resolution
- double blind