Challenges in Psoriasis Research: A Systematic Review of Preclinical Models.
Ana Ubago-RodríguezMaría I Quiñones-VicoManuel Sánchez-DíazRaquel Sanabria-de la TorreÁlvaro Sierra-SánchezTrinidad Montero-VílchezAna Fernández-GonzálezSalvador Arias-SantiagoPublished in: Dermatology (Basel, Switzerland) (2024)
Therefore, this review summarizes the current preclinical models (in vivo, in vitro, and ex vivo), discussing how to develop them, their advantages, limitations, and applications. There are many challenges to improve the development of the different models. However, research in these in vitro model studies could reduce the use of animals. This is favored with the use of future technologies such as 3D bioprinting or organ-on-a-chip technologies.