HDAC6/HNF4α loop mediated by miR-1 promotes bile acids-induced gastric intestinal metaplasia.

Na WangMin ChenZhen NiTing LiJiaoxia ZengGuofang LuJiaojiao WangJian ZhangSiran WuYong Quan Shi

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2020)

Our findings show that the HDAC6/HNF4α loop regulated by miR-1 plays a critical role in gastric IM. Blocking the activation of this loop could be a potential approach to preventing BA-induced gastric IM or even gastric cancer (GC).

Keyphrases

cell proliferation
long non coding rna
high glucose
diabetic rats
transcription factor
long noncoding rna
histone deacetylase
drug induced
endothelial cells
oxidative stress
inflammatory response
high resolution
climate change
liquid chromatography