Tumour-derived CSF2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas.
Malgorzata SielskaPiotr PrzanowskiMaria PasierbińskaKamil WojnickiKatarzyna PoleszakBartosz WojtasDominika GrzeganekAleksandra Ellert-MiklaszewskaMin-Chi KuHelmut KettenmannBozena KaminskaPublished in: British journal of cancer (2020)
CSF2 is overexpressed in a subset of mesenchymal GBMs in association with high immune gene expression. Tumour-derived CSF2 attracts, supports survival and induces pro-tumorigenic polarisation of microglia and macrophages.