Tumour-derived CSF2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas.

Malgorzata SielskaPiotr PrzanowskiMaria PasierbińskaKamil WojnickiKatarzyna PoleszakBartosz WojtasDominika GrzeganekAleksandra Ellert-MiklaszewskaMin-Chi KuHelmut KettenmannBozena Kaminska

Published in: British journal of cancer (2020)

CSF2 is overexpressed in a subset of mesenchymal GBMs in association with high immune gene expression. Tumour-derived CSF2 attracts, supports survival and induces pro-tumorigenic polarisation of microglia and macrophages.

Keyphrases

gene expression
bone marrow
dna methylation
stem cells
single cell
high grade
cerebrospinal fluid
cell therapy
dendritic cells
acute myeloid leukemia
inflammatory response
peripheral blood
anti inflammatory
neuropathic pain
mesenchymal stem cells
spinal cord
spinal cord injury