Prospective evaluation of drug-drug interactions in ambulatory cancer patients initiated on prophylactic anticoagulation.

Hank K NgBritny G RogalaSteven AdesJoanna R SchwartzTakamaru AshikagaPamela VacekChris E Holmes

Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2020)

DOACs had fewer DDIs than warfarin, although interaction severity differed between anticoagulants. Some anticoagulant-drug interactions were associated with bleeding or VTE. Although not powered for analysis, DDI severity did not affect bleeding rates and inversely correlated with VTE risk.

Keyphrases

venous thromboembolism
direct oral anticoagulants
atrial fibrillation
blood pressure
oral anticoagulants
emergency department
data analysis