Predicting chemoresponsiveness in epithelial ovarian cancer patients using circulating small extracellular vesicle-derived plasma gelsolin.

Emma GerberMeshach Asare-WereheneArkadiy ReunovDylan BurgerTien LeEuridice CarmonaAnne-Marie Mes-MassonBenjamin K Tsang

Published in: Journal of ovarian research (2023)

Total pGSN/sEV-pGSN was the best predictor of chemoresponsiveness prior to treatment, outperforming the individual biomarkers (CA125, total pGSN, and sEV-pGSN). This multianalyte predictor of chemoresponsiveness could help to inform physicians' treatment and follow up plan at the time of EOC diagnosis, thus improving patients' outcomes.

Keyphrases

end stage renal disease
primary care
ejection fraction
peritoneal dialysis
combination therapy
patient reported outcomes
skeletal muscle
replacement therapy