Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging.
Husam BensretiDima W AlhamadAlejandro Marrero GonzalezManuel Pizarro-MondesirWendy B BollagCarlos M IsalesMeghan E McGee-LawrencePublished in: Current osteoporosis reports (2022)
Harmful effects of GCs on bone mass involve several cellular pathways and events that can include BMSC differentiation bias toward adipogenesis and the influence of mature BMAT on bone remodeling through crosstalk. Interestingly, BMAT involvement remains poorly explored in GC-induced osteoporosis and warrants further investigation. This review provides an update on the current understanding of the role of glucocorticoids in the biology of osteoblasts and bone marrow adipocytes (BMAds).
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