Wnt5a/β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration.

Dandan LiuJingxiao DuHai XieHaibin TianLixia LuChaoyang Zhang Guo-Tong Xu Jingfa Zhang

Published in: Journal of neuroinflammation (2024)

Our study reveals a reciprocal activation between Wnt5a and β-catenin to mediate EMT as a pivotal driver of subretinal fibrosis in nAMD. This positive feedback loop provides valuable insights into potential therapeutic strategies to treat subretinal fibrosis in nAMD patients.

Keyphrases

epithelial mesenchymal transition
age related macular degeneration
cell proliferation
end stage renal disease
transforming growth factor
signaling pathway
stem cells
newly diagnosed
chronic kidney disease
ejection fraction
peritoneal dialysis
liver fibrosis
vascular endothelial growth factor